In Islamic literature, it is considered one of the greatest forms of healing medicine. It has been recommended for regular use in Tibb-e-Nabwi (Prophetic Medicine).

Nigella sativa (N. sativa) (family Ranunculaceae) is a widely used medicinal plant throughout the world. It is very popular in various traditional systems of medicine like Unani and Tibb, Ayurveda, and Siddha.

In Islamic literature, it is considered one of the greatest forms of healing medicine. It has been recommended for regular use in Tibb-e-Nabwi (Prophetic Medicine).

Estimation of the World Health Organisation

It is estimated by the World Health Organisation (WHO) that most of the world’s population depends on herbal medicine for their health care. It is one of the most common medicinal plants worldwide and contains many useful chemical constituents.

Extensive studies on N. sativa have been carried out by various researchers, and a wide spectrum of its pharmacological actions have been explored. Many scientific studies have reported that the black seed oil of Nigella sativa possesses immune-modular properties because it contains at least 60% of the daily need for unsaturated fatty acids.

Some of the unsaturated fatty acids cannot be formed by the human body, so they have to be taken externally.

A teaspoon of black seed oil mixed with yoghurt is given to children from the age of 4 years as a healthy dietary supplement. Large-scale clinical studies are still needed to prove the clinical efficacy of this herb, especially in skin diseases, immunomodulatory disorders, and cancers.

As per the data of the reported studies, thymoquinone is considered an active constituent with various biological properties like wound healing, anti-diabetic, anti-inflammatory, antidiabetic, antidepressant, nephroprotective, antibacterial, anti-viral, antifungal, etc.

Many clinical studies are suggesting that Nigella sativa possesses a wide range of benefits for skin disorders. The present study has been carried out to determine the effects of Nigella sativa on the lipid profile of cardiac patients visited at the Ch.Pervaiz Elahi Institute of Cardiology, Multan.

In conclusion, Nigella sativa is effective in changing the lipid profile significantly in a way that is beneficial to the heart.

Until now, no specific and effective treatment exists for coronavirus disease 2019 (COVID19). Since honey and Nigella sativa (HNS) have many properties, we tested their efficacy for this disease in a multicenter, placebo-controlled, and randomised clinical trial at four medical care facilities in Pakistan.

NARC-Kaonji has been developed by the Institute of Agri-Biotechnology and Genetic Resources, National Agricultural Research Centre (IABGR, NARC), Islamabad. A promising line was selected from indigenous germplasm collected from the Lahore area during 2002–2003 and given the number MP120.

It was observed that kalonji could be successfully cultivated in most parts of the country during the months of October and November. The present study was conducted on the physicochemical properties of oil extracted from Kalonji seeds (Nigella sativa L.) and commercial oil samples available in Pakistan.

To determine the analgesic effect of ethanolic extract of Nigella sativa seeds on experimentally-induced pain in albino mice, experiments were carried out, which resulted in the finding that ethanolic extract of Nigella sativa possessed a significant analgesic effect in mice.

It is important to prove or disprove the effectiveness, safety, and tolerability of powdered N. sativa (Kalonji) seed in capsules on serum lipid levels, blood sugar, blood pressure, and body weight in adults.

A favourable impact of powdered N. sativa (Kalonji) seed in capsules was noted on almost all variables, but results were not statistically significant.

A larger study with an adequate sample size is recommended. The crude extract of Nigella sativa seeds exhibits spasmolytic and bronchodilator activities mediated possibly through calcium channel blockade, and this activity is concentrated in the organic fraction.

Its usefulness for diarrhoea and asthma in traditional medicine appears thus to be based on a sound mechanistic background. Montelukast and N. sativa both demonstrated a significant and early decrease in daytime as well as ophthalmic symptoms, while montelukast showed diminished and late effects on nighttime symptoms when compared with N. sativa.

N. sativa seed powder (NS), its extracts, and purified fractions were studied for their possible gastroprotective effects in indomethacin-treated rats (adult albino male rats weighing 180–220 g) to rationalise the folkloric uses. Nigella sativa (black cumin) seed could be the most suitable alternative to antibiotics in poultry nutrition.

Nigella sativa not only promotes birds’ health and production performance but also plays a significant role as a natural antioxidant and immunostimulant. The study was conducted to investigate the effect of different levels of feed-added black seed (Nigella sativa L.) on the overall performance and immunity of broiler chicks at NWFP Agricultural University, Peshawar, in May 2005.

Myocardial injury constitutes a major cause of morbidity and mortality in humans. The present study aimed to investigate the protective role of thymoquinone, which is an active principle of Nigella sativa (N. sativa) seed (commonly called black seed), in isoproterenol-induced myocardial injury, a classical example of excess catecholamines related to coronary insufficiency and ‘stress cardiomyopathy’.