Rats: Model for Rheumatoid Arthritis its efficiency and Conclusion

Rheumatoid arthritis is a chronic inflammatory disease involving muscular and skeleton system effecting almost 0.5 to 1% of adult population.

Rats: Model for Rheumatoid Arthritis its efficiency and Conclusion

Animals are awesome creation of nature.  For thousands of years Humans and animals are living together. Both are benefitting each other in different ways. Humans using animals for invention and experimentations. So far drugs against many diseases were made by humans. These drugs not only reduced the burden of various diseases but also helpful in maintaining good health of humans. Different animals models used for different purposes like members of murids  are using as a model for experimental many drugs used for treatment of arthritis. Similarly, for discovery of anticancer different animals are used.

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Rheumatoid arthritis is a chronic inflammatory disease involving muscular and skeleton system effecting almost 0.5 to 1% of adult population. This disease causes a joint destruction results in functional disability ability causing adverse effects on human health.

Different health associations worked a lot in determining the epidemiology of Rheumatoid arthritis throughout the globe. According to research in year 2010 prevalence of Rheumatoid arthritis is 0.24%. In united states and northern European countries this prevalence is quite high almost 0.5 to 1 %. In united states and Northern European countries almost 40 from 100000 people were suffering from arthritis.

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Sign and symptoms:

following are sign and symptoms of rhino arthritis in humans.

  • pain and swelling of joints
  • unable to walk properly
  • stiffness of joints
  • functional disability of joints especially hands and feet
  • loss of weight
  • weaken of immunity system

For arthritis treatment different drugs were made. The efficacy of these drugs were tested on rats. There are many reasons why we select rats for these experiments. Rats are small in size Rats are lab animals can be controlled easily. Rats need small concentrations of drugs to induce arthritis. The genetic make up rats and humans are almost same so effect of drug on both species are same.

Experimental Drugs:

Different drugs have been used on rats as an experimental drug for the treatment of arthritis

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Like.

  • Pain killer (tramadol, hydrocodone)
  • NSAID (Ibufen, naproxen)
  • Counterirritants (creams, gels)
  • Disease-modifying antirheumatic drugs (methotrexate, hydroxychloroquine)
  • Corticosteroids (prednisone, cortisone)

After a lot of experiments many different drugs were discovered for the treatment of arthritis in humans. Rabbits usually very active animals.

conclusions:

Arthritis is very important disease regarding old age in humans that normally present in every 3 out of 10 persons. Different experiments have been performed to discovered exact treatment of arthritis in humans. A lot of improvement has been done regarding this disease but still there is a space for all researchers to work on it and reduce this disease to its minimum

Author:  Dr. Muhammad Umair Murtaza

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